Juläine
The next-generation biostimulator from Swedish company Nordberg Medical: poly-L-lactic acid microspheres with LaSynPro technology. We use it when cheekbones, cheeks and jawline need gradual, even support.
Polylactic acid · Calcium hydroxylapatite
Collagen biostimulators in Milan
Juläine, Juvelook, Sculptra and Radiesse restore support to cheekbones, cheeks and jawline by stimulating the collagen your face makes on its own. Performed by doctors at Via Sant'Andrea 21.
The KinAura method
Volume you build yourself
A biostimulator works with your own collagen, which is why the result builds gradually and looks natural. In studies on poly-L-lactic acid, the improvement lasted up to 25 months after the last session.
Always a doctor
Every injection at KinAura is performed by an aesthetic medicine doctor, who chooses product and technique for your face.
Free consultation
Your first consultation is free and includes the Aura 3D scan, which measures the volumes of your face.
At a glance
What is a biostimulator
An injectable the body absorbs slowly and which, as it does, prompts fibroblasts to make new collagen. Facial support comes back from within, little by little.
- Sessions 1–3sessions
- Depending on the product and the volume to rebuild.
- Interval 4–6weeks
- The time it takes for collagen to start forming.
- Result 2–3months
- Gradual, growing week after week.
- Duration 2years
- Up to two years with poly-L-lactic acid.
Filler or biostimulator
Fill or rebuild
When the face loses volume, at KinAura we prefer latest-generation biostimulators to filler: they work on the cause, the collagen that declines with age.
- Comparison
- Hyaluronic acid filler
- Biostimulator
- How it works
- Adds volume with a gel
- Stimulates the collagen you make
- When you see it
- Straight away
- Gradually, over two to three months
- How long it lasts
- 6–12 months
- Up to two years with poly-L-lactic acid
- The result
- Defined volume, point by point
- Diffuse support and denser skin
How it works
Two molecules, one goal
Polylactic acid and calcium hydroxylapatite reach collagen along different paths. Choose a molecule to see what happens in the dermis.
PLLA and PDLLA
Microparticles of a biocompatible polymer, the same material used for decades in absorbable surgical devices. In the deep dermis they dissolve slowly into lactic acid and meanwhile activate fibroblasts: a network of new collagen forms around each particle and stays after the product is gone.
85%In a randomised multicentre study, 25 months after the last session more than 85% of patients treated with poly-L-lactic acid were still rated as improved by the evaluating doctors.
Sources: Narins et al., J Am Acad Dermatol 2010 (PubMed 20159311) · Brandt et al., Aesthet Surg J 2011 (PubMed 21719865)
CaHA, Radiesse
Smooth microspheres of 25–45 microns, made of a mineral found in bones and teeth, suspended in a gel. The gel gives support straight away; over the following months the microspheres become a scaffold on which fibroblasts lay down collagen and elastin. Diluted, hydroxylapatite works on skin quality of the neck and décolletage.
9monthsIn a split-face biopsy study, at 4 and 9 months calcium hydroxylapatite produced more elastin and more physiological collagen remodelling than a hyaluronic acid filler.
Sources: Yutskovskaya et al., J Drugs Dermatol 2014 (PubMed 25226004) · Yutskovskaya and Kogan, J Drugs Dermatol 2017 (PubMed 28095536)
Collagen time
What happens, month by month
- Today
The session
The doctor places the product deep in the tissue. Any swelling in the first days settles quickly.
- 6 wks
Collagen starts
Fibroblasts begin producing new fibres. This is when the next session takes place, if planned.
- 3 mths
The result takes shape
Denser skin, better supported cheekbones and jawline. We check it with a new Aura scan.
- 25 mths
It lasts
In studies on poly-L-lactic acid, improvement was measured up to 25 months after the last session.
The products we use
Juläine, Juvelook, Sculptra, Radiesse
Four biostimulators with different molecules and indications. The doctor chooses based on the area, skin thickness and the volume to rebuild.
Juvelook
Made in Korea by Vaim, it combines poly-D,L-lactic acid with non-cross-linked hyaluronic acid. Hyaluronic acid hydrates straight away, PDLLA builds collagen over the following weeks. Ideal for texture, pores, fine lines and acne scars.
Sculptra
The benchmark biostimulator, the one behind the studies that measured results up to 25 months. It works deep on volume and density, usually in two or three sessions six weeks apart.
Radiesse
Calcium hydroxylapatite microspheres in a gel. It gives immediate support to cheekbones and jaw and stimulates collagen and elastin over the following months. Diluted, it improves skin quality on the neck, décolletage and hands.
Aura analysis
We measure volume in 3D
Aura rebuilds your face and neck in three dimensions. Next-generation imaging, Swiss technology, clinical precision.
- 01
Volumes and proportions
On the 3D model the doctor measures the angles and distances of your face.
- 02
Where support is missing
The map shows where volume has dropped and guides the choice of product and areas.
- 03
Before and after
We repeat the scan and compare volumes on the same map, month after month.
The areas
Where biostimulators work
On the face they rebuild the support lost over the years. On the neck, décolletage and hands they improve skin thickness and quality.
CheekbonesThe anchor of the midface and the first area to hollow. Restoring support here lifts the whole look.
CheeksFullness returns gradually, without a puffy look.
JawlineThe contour of the face becomes more defined and the jawline sharper.
TemplesAn often overlooked detail: filling them freshens the whole look.
Neck, décolletage and handsThicker, more elastic skin and softer lines; on the back of the hands it veils tendons and veins.
The KinAura protocol
From the scan to follow-up
- 01
Consultation and Aura
The doctor examines you and Aura measures the volumes of your face in 3D. The consultation is free.
- 02
Your plan
Product, areas and number of sessions. If you also need firmness, we add XERF.
- 03
The sessions
Fine needle or microcannula, in one or more sessions four to six weeks apart.
- 04
Follow-up
At two to three months we repeat the Aura scan and check the result on the volumes.
One of the treatment rooms at Via Sant'Andrea 21.
Before and after
What to do, what to avoid
Before the session
- If you take blood thinners or supplements that thin the blood, such as omega 3 or vitamin E, tell the doctor.
- Avoid alcohol the evening before: it lowers the risk of small bruises.
- If you have dental work or an important event coming up, tell the doctor so you can pick the right date.
After the session
- Mild swelling and a few small bruises can last a few days.
- For some products, such as Sculptra, the doctor will show you a massage to do at home over the following days.
- For 48 hours, no intense exercise, sauna or steam room.
- For two weeks, postpone facial massages and treatments that press on the treated areas.
Biostimulators and XERF
Volume and firmness
Biostimulators rebuild support from within. When the skin has also lost tone, we pair them with XERF, which works on firmness with radiofrequency.
Every session at KinAura is performed by a doctor. Meet the medical team
BiostimulatorsLost volume and support of cheekbones, cheeks and jawline.
XERFSkin firmness and a better defined contour.
BiorevitalisationSkin quality with polynucleotides and PDRN. Discover biorevitalisation
FAQ
What people ask us most
If your question is not here, message us: our reception replies and, when needed, the doctor.
What are collagen biostimulators?
Injectables that the body absorbs slowly and which, in the meantime, prompt fibroblasts to make new collagen. The most used are polylactic acid, such as Juläine, Juvelook and Sculptra, and calcium hydroxylapatite, such as Radiesse.
Biostimulators or filler: what is the difference?
Hyaluronic acid filler fills immediately with a gel and usually lasts 6 to 12 months. A biostimulator works on your own collagen: the result builds gradually over two to three months, looks more natural and with poly-L-lactic acid can last up to two years.
How long do biostimulators last?
With poly-L-lactic acid, studies measured improvement up to 25 months after the last session. With calcium hydroxylapatite a top-up is usually planned between 12 and 18 months.
How many sessions do I need?
One to three, four to six weeks apart. Sculptra is usually done in two or three sessions; the number depends on the product and the volume to rebuild.
When will I see the result?
With Radiesse support is visible straight away and improves over the following months. With polylactic acid the result is gradual and takes shape over two to three months.
What is the difference between Juläine, Juvelook, Sculptra and Radiesse?
Juläine and Sculptra are poly-L-lactic acid and work deep on volume and support. Juvelook combines poly-D,L-lactic acid and hyaluronic acid and is ideal for skin quality. Radiesse is calcium hydroxylapatite: it gives immediate support and, diluted, improves the neck, décolletage and hands.
Will it look natural?
Yes. The volume comes from your own collagen and grows gradually, so your face stays yours and nobody notices a sudden change.
Does it hurt?
The doctor uses a fine needle or a microcannula and, when needed, local anaesthetic. It is well tolerated and you can go straight back to your day.
What should I do after the session?
Mild swelling and a few small bruises can last a few days. For some products, such as Sculptra, the doctor will show you a massage to do at home. Avoid intense exercise, sauna and steam room for 48 hours.
Can they be combined with XERF?
Yes. Biostimulators rebuild volume, XERF works on skin firmness: when you need both we include them in the same plan.
Which areas can be treated?
Cheekbones, cheeks, jawline and temples. On the neck, décolletage and hands they improve skin thickness and quality.
How much do biostimulators cost?
It depends on the product, the areas and the number of sessions. You receive the full plan in clinic before starting.
Do I need a consultation first?
You can book the treatment or a consultation. The consultation is free and includes the Aura 3D scan, which measures the volumes of your face.
KinAura in the press
By appointment
Your face at Via Sant'Andrea
Book the treatment or a free consultation. We start from the Aura scan and choose the right biostimulator together.
Via Sant'Andrea 21, MilanTel. +39 392 548 1654Mon–Fri 9–19
Scientific sources
- Narins RS, Baumann L, Brandt FS, et al. A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol. 2010;62(3):448-62. doi:10.1016/j.jaad.2009.07.040
- Brandt FS, Cazzaniga A, Baumann L, et al. Investigator global evaluations of efficacy of injectable poly-L-lactic acid versus human collagen in the correction of nasolabial fold wrinkles. Aesthet Surg J. 2011;31(5):521-8. doi:10.1177/1090820X11411161
- Yutskovskaya Y, Kogan E, Leshunov E. A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler. J Drugs Dermatol. 2014;13(9):1047-52. PubMed 25226004
- Yutskovskaya YA, Kogan EA. Improved Neocollagenesis and Skin Mechanical Properties After Injection of Diluted Calcium Hydroxylapatite in the Neck and Décolletage: A Pilot Study. J Drugs Dermatol. 2017;16(1):68-74. PubMed 28095536
- Massidda E. Starting Point for Protocols on the Use of Hyperdiluted Calcium Hydroxylapatite (Radiesse) for Optimizing Age-Related Biostimulation and Rejuvenation of Face, Neck, Décolletage and Hands: A Case Series Report. Clin Cosmet Investig Dermatol. 2023;16:3427-3439. doi:10.2147/CCID.S420068
- Seo SB, Park H, Jo JY, Ryu HJ. Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: A preliminary study. J Cosmet Dermatol. 2024;23(3):794-802. doi:10.1111/jocd.16085
